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KMID : 1130320160590060271
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Korean Journal of Pediatrics
2016 Volume.59 No. 6 p.271 ~ p.275
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Clinical importance of F-waves as a prognostic factor in Guillain-Barre syndrome in children
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Lee Eung-Bin
Lee Yun-Young
Lee Jae-Min
Son Su-Min
Hwang Su-Kyeong
Kwon Soon-Hak
Kim Sae-Yoon
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Abstract
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Purpose: A limited number of studies have examined the link between F-wave abnormalities and clinical presentation in pediatric Guillain-Barre syndrome (GBS). Therefore, this study examined the importance of F-wave abnormalities as a prognostic factor in pediatric GBS patients.
Methods: The records and electrodiagnostic studies (EDS) of 70 GBS patients were retrospectively evaluated, and divided into 2 groups according to the results of EDS. Group A (n=33) presented with F-wave abnormalities, and group B (n=26) exhibited normal findings. We compared laboratory reports, clinical features, response to treatment, and prognosis between the 2 groups.
Results: Motor weakness was the most frequently observed symptom for either group. Clinically, the incidence of fever and upper respiratory symptoms differed between the 2 groups, while the prevalence of abnormal deep tendon reflex (DTR) was significantly higher in group A than B (P<0.05). Patients diagnosed with GBS had received intravenous immunoglobulin treatment: 94% in group A and 58% in group B. Furthermore, significantly greater numbers of patients in group A showed H-reflex abnormalities and poor prognosis compared with group B (P<0.05).
Conclusion: This study demonstrated that F-waves are a clinically important prognostic factor in GBS. F-wave abnormalities were associated with abnormal DTR and poor prognosis in patients. Limited studies have examined the link between F-wave abnormalities and clinical results; therefore, further randomized controlled studies are needed to confirm the clinical characteristics and efficacy of treatments.
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KEYWORD
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Guillain-Barre syndrome , Acute inflammatory demyelinating polyradiculopathy , F-wave , Nerve conduction velocity
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